N-Acetylcysteine amide Synonyms N-Acetyl-L-cysteinamide
N-Acetyl-L-cysteinamide
CAS: 38520-57-9
Molecular Formula: C8H14N2O5S2
N-Acetylcysteine amide Synonyms N-Acetyl-L-cysteinamide - Names and Identifiers
N-Acetylcysteine amide Synonyms N-Acetyl-L-cysteinamide - Physico-chemical Properties
| Molecular Formula | C8H14N2O5S2 |
| Molar Mass | 282.33716 |
| Density | 1.226±0.06 g/cm3(Predicted) |
| Melting Point | 147-149 °C(Solv: ethanol (64-17-5)) |
| Boling Point | 441.0±40.0 °C(Predicted) |
| Water Solubility | H2O: ≥20mg/mL |
| Appearance | 形态 lyophilized powder 颜色 white to off-white |
| pKa | 9.21±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Use | N-acetylcysteine amide is an antioxidant that can penetrate cell membrane, has anti-inflammatory activity, and can regulate NF-κB activation, HIF-1α and ROS. |
N-Acetylcysteine amide Synonyms N-Acetyl-L-cysteinamide - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
N-Acetylcysteine amide Synonyms N-Acetyl-L-cysteinamide - Target
| Target | Value |
| NF-κ B () |
|
| HIF-1α () |
|
| ROS () |
Last Update：2024-04-10 22:29:15
N-Acetylcysteine amide Synonyms N-Acetyl-L-cysteinamide - Research
In vitro studies
N-Acetylcysteine amide shows no obvious effect on the viability of H9c2 cells treated with doxorubicin (DOX) at < 1 mM, but causes significant cytotoxicity at 10-20 mM. N-Acetylcysteine amide (750 μM) reduces the ROS levle and lipid peroxidation induced by DOX, and restores GSH/GSSG ratio and activities of antioxidant enzymes, such as catalase (CAT), gluthathione peroxidase (GPx), gluthathione reductase (GR). N-Acetylcysteine amide (1 mM) protects the human brain microvascular endothelial (HBMVEC) from methamphetamine (METH)- induced cell death.
In vivo studies
N-Acetylcysteine amide has increased CNS bioavailability. N-Acetylcysteine amide (150 mg/kg, I .p.) improves cortical sparing and functional outcome, reduces oxidative stress, improves mitochondrial bioenergetics, and maintains mitochondrial glutathione content following traumatic brain injury (TBI) in rats.
Last Update：2024-04-10 22:43:14
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Product Name: Acetylcysteine Impurity 14 Visit Supplier Webpage Request for quotationCAS: 38520-57-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: AC-L-CYS-OH Visit Supplier Webpage Request for quotation
CAS: 38520-57-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 38520-57-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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